Novel Drug Delivery in Dermatology

Botanix has an exclusive license to use a proprietary drug delivery system called Permetrex™, for direct skin delivery of pharmaceuticals. This platform technology is at the heart of Botanix’s product pipeline, providing a targeted and effective mode of delivery for a range of novel treatments – including synthetic cannabidiol or CBD.

Novel skin delivery technology

Synthetic Cannabinoids

Permetrex™ – Skin Delivery Technology

Delivering pharmaceuticals to the skin to treat disease is challenging. The skin’s role is to protect the body from a range of chemical and environmental assaults, so bypassing this active system requires an innovative approach. Botanix has exclusively licensed a novel transdermal drug delivery solution known as Permetrex™, which is designed to deliver pharmaceuticals through the skin more effectively. Right to where treatment is needed most.

So what makes Permetrex™ unique?

It does not utilise chemicals which have a tendency to dry the skin and are therefore undesirable for diseases such as acne, psoriasis and atopic dermatitis;
It creates substantial chemical potential when applied to the skin, which facilitates the rapid delivery of active pharmaceutical ingredients across the stratum corneum and into the lower layers of the skin;
It can accommodate other chemicals which can selectively leave parts of the formulation on the skin in a protective coating for extended absorption and/or protection of the skin;
Transdermal delivery avoids the ‘first-pass’ effect of liver metabolism, potentially enabling lower dosage levels of active pharmaceutical ingredients to be rapidly and reliably absorbed with high bioavailability.

Botanix is currently actively working with pharmaceutical partners who are using the Permetrex™ delivery system.

Permetrex™ drives pharmaceuticals deep into the skin where their action is required – otherwise the drug remains in the outer layers of the skin.

Synthetic Cannabinoids

Cannabinoids were originally identified in the Cannabis Sativa plant and include the well-known molecule cannabidiol or ‘CBD.’ Plant-derived CBD has been touted as a cure-all for a range of health ailments including pain, anxiety, insomnia, depression, and more. The missing piece? A wide body of reputable clinical evidence, so regulators can ensure it is safe and effective for use.

Botanix has an evidence-first approach. To support this, we have purposefully invested our energy in investigating and proving the merits of a safer, purer and more cost effective synthetic form of CBD which avoids the challenges of naturally extracted CBD. We are also developing novel synthetic cannabinoid derivatives with an intent to increase the potency, while retaining desirable safety properties of CBD.