Boston Herald AMR op-ed

Co-founder, president and CEO of Venatorx Pharmaceuticals, Christopher J. Burns PhD, and co-founder and CEO of Spero Therapeutics, Ankit Mahadevia, have joined forces to publish a powerful opinion editorial in the Boston Herald.

Their article, ‘Pasteur Act can reinvigorate broken antibiotic market’, investigates how this legislation can work to prevent over-subscribing of antibiotics and incentivised development of novel antibiotics, during an escalating global public health crisis caused by drug-resistant infection.

A brief excerpt:

‘Researchers warn that without new antibiotics, drug-resistant infections could kill 10 million people annually by 2050. Currently, they kill 700,000 per year, worldwide, and contribute to an additional $4.6 billion in increased health care costs per year in the United States alone.’

It highlights the importance of continued R&D in this space – something Botanix is proud to be prioritising with our BTX 1801 development program.

Read the full article here.

ABC News | Mask rules leads to rise in skin conditions

Skin specialists have reported an increase in people seeking treatment for skin conditions as a result of mandatory mask wearing in Australia due to COVID-19. 

Dubbed  ‘maskne’, the condition includes acne, rosacea flare ups, perioral dermatitis, and folliculitis, all of which are aggravated by substances such as oil, bacteria, and dead skin cells becoming trapped under the mask.

Read the full article on the ABC website here.

Investor Conference Call

Botanix Pharmaceuticals President and Executive Chairman, Vince Ippolito, and Executive Director, Matt Callahan, hosted an investor conference call on Friday 7 May 2021.

You may listen to the audio file here:

Ticker News Interview

Botanix Pharmaceutical’s (ASX:BOT) Executive Director, Matt Callahan, spoke with the Ticker News team yesterday to detail the next phase of our BTX 1801 antimicrobial program, which will target nasal decolonisation of Staph aureus in haemodialysis patients.

Investor Presentation + Conference Call

Botanix Pharmaceuticals has today released an updated investor presentation and registration details for a conference call with our investors and supporters.

participants can pre-submit questions to be answered at the end of the call, when registering through the link below.

See the updated investor presentation here.

Conference call details:

Date: Friday, 7 May 2021

Time: 11:00am AEST

Registration details:

Participants are encouraged to pre-register for the conference call. Upon registration, participants will receive a unique pin granting fast-track access to the conference call and the opportunity to submit questions to our team.

Register now.

BTX 1801 Clinical Development Update

Botanix Pharmaceuticals has today released a comprehensive update and presentation on imminent plans for the BTX 1801 antimicrobial platform program.

The next phase of development for BTX 1801 will focus on targeting the nasal decolonisation of Staph aureus in haemodialysis patients, which represents a significant market opportunity to prevent bloodstream infections in these patients.

Dialysis largely replicates the functions of the kidneys in patients with chronic kidney failure, with dialysis taking over the key functions of the kidneys (including filtering and removing waste materials from the body).  Haemodialysis patients undergoing ongoing dialysis regularly (e.g. three to five times per week), are at a high risk of bloodstream infections, due to their treatment requiring frequent use of catheters which in the first year are routinely central lines with direct access to the heart.

Our team is energised by the opportunity to develop a novel approach for removing sources of bacteria to prevent bloodstream infections in haemodialysis patients – which is desperately needed. Our prior work to examine the unique bactericidal mechanism of action of synthetic cannabidiol provides great confidence for this program too.

Read today’s ASX release and presentation here.

New AMR publication

Botanix Pharmaceutical’s ground-breaking research on the antimicrobial potential of cannabidiol (CBD) has been published by a leading South American academic group in BioRxiv.

The BioRxiv article confirms our discovery that synthetic CBD can also kill a select group of Gram-negative bacteria, including the bacteria responsible for the sexually transmitted disease gonorrhoea and the increasingly challenging Clostridioides difficile (C.Diff) infections.

The BioRxiv Paper follows the publication of our research in Nature Research’s peer-reviewed journal Communications Biology in January 2021, which is continuing to drive conversation around the potential of CBD to address antimicrobial resistance, globally.

Read today’s ASX release.

Freethink Feature Article

Senior writer for Freethink, B.David Zarley, has published a feature article titled ‘Can CBD be the Next Superbug Slayer?’

It examines the importance Botanix’s research into the antimicrobial potential of cannabidiol and includes comments from Dr Mark Blaskovich, Director of UQ’s IMB Centre for Superbug Solutions and collaborator on our BTX 1801 antimicrobial research.

Read the Freethink article here.

“The Superbug Era” – ABC documentary

Addressing the pressing global emergency of antimicrobial resistance (AMR) is central to our work at Botanix Pharmaceuticals (ASX:BOT). Our BTX 1801 antimicrobial platform program is designed to offer novel treatments and solutions, leveraging the unique power of synthetic CBD.

This week, the ABC in Australia aired the final episode of its three-part Invisible Wars documentary series titled, “The Superbug Era”. It features Dr Mark Blaskovich, an AMR expert from the University of Queensland, who is playing a key role in the development of Botanix’s AMR platform, alongside other leading experts in this space.

The documentary is narrated by respected health commentator, Dr Norman Swan, who has been leading the national broadcaster’s coverage on the COVID-19 pandemic too. What it illuminates, in clear view, is the urgent need for novel solutions like BTX1801. Here’s an excerpt:

“When COVID-19 swept around the globe it revealed how incredibly vulnerable we are to infections for which we have no cure. Scientists are now warning of a new kind of pandemic, that could transform many treatable diseases into unstoppable killers. It’s the very real threat of antibiotic resistance. Antibiotic resistance is one of the biggest man-made threats of the modern age.”

Watch ABC Documentary here.

Australian medicinal cannabis revenue tipped to reach $200 million in 2021

Australian medicinal cannabis revenue is tipped to double this year amid growing confidence in the emerging sector. And WA is poised to maintain a significant hold of the market share.

While the State is recognised globally for its optimal growing conditions, local cultivators, manufacturers and researchers have also benefited from limited COVID-19 interference in their operations.

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Dr Washer said the trials were critical for the future success of the business.

“Mainstream medicine is where you want to be, and you need the right data to achieve this,” he said. “This is what makes a company attractive to big pharmaceuticals.”

Synthetic medicinal cannabis is more expensive to produce but is more accurate in eradicating THC, the compound in recreational marijuana that produces the “high” sensation.

Dr Washer said having cannabis products that were 100 per cent THC-free would be important to receive US Food and Drug Administration approval.

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Click through to read the full article on The West Australian.